The brain has an amazing ability to reconfigure itself. During the initial stages of brain development cortical connections are formed and pruned based partially on the experiences of an individual and partially based on the genetic information inherited at birth. However, even long after this initial forming of the connectivity in the brain external factors can lead to significant changes in how the brain functions. These can be small adjustments that slightly alter the strength of different connections based on learning, or it can be a dramatic change triggered by the loss of function in an entire subsystem through a stroke or another form of permanent damage. Dr. Ione Fine has studied the pasticity of the brain and has worked with an intruiging patient who regained sight after forty years of blindness. In the interview she describes the consequences of this dramatic change in the way her patient perceived the world.